|
KMID : 1149220100180020201
|
|
Korean Journal of Oriental Medical Prescription
2010 Volume.18 No. 2 p.201 ~ p.213
|
|
|
Fermented Soybean Powder Reduces Body Weight Gain and Improves Hepatic Lipid Accumulation in High Fat Diet-Fed Obese Male C57BL/6N Mice
|
|
Tsung Pei-Chin
Lee Hee-Young
Lee Hye-Rim
Jeong Hae-Gyeong
Yin Yuan-Mi
Yoon Mi-Jung
Park Sun-Dong
Shin Soon-Shik
|
|
|
Abstract
|
|
|
Objective : We investigated the effects of fermented soybean(FSOB) on body weight and examined whether hepatic lipid accumulation are inhibited by it in high fat diet-fed obese male mice.
Methods: 8 weeks old, high fat diet-fed obese male mice were divided into 5 groups: C57BL/6N normal, control, FSOB(1), (2) and (3). After mice were treated with FSOB for 9 weeks, we measured body weight gain, food intake, feeding efficiency ratio, fat weight, plasma leptin and lipid levels. We also did histological analysis for liver and fat on the mice.
Results: 1. Compared with controls, FSOB-treated mice had lower body weight gain and adipose tissue weight, the magnitudes of which were prominent in FSOB(3) and FSOB(1). 2. Compared with controls, FSOB-treated mice had lower feeding efficiency ratio and blood plasma leptin levels, the magnitude of which was prominent in FSOB(3). 3. Compared with controls, FSOB-treated mice had lower blood plasma total cholesterol and LDL-cholesterol levels. 4. Blood plasma AST and ALT concentrations were not changed by FSOB, indicating FSOB do not show any toxic effects. 5. Consistent with their effects on body weight gain, the size of adipocytes were significantly decreased by FSOB, whereas the adipocyte number per unit area was significantly increased, suggesting that FSOB decreased the number of large adipocytes. Hepatic lipid accumulation was decreased by FSOB.
Conclusions : These results demonstrate that FSOB effectively reduces body weight gain, feeding efficiency ratio, blood plasma leptin level and improves hepatic lipid accumulation.
|
|
|
KEYWORD
|
|
|
fermented soybean, body weight gain, hepatic lipid accumulation
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|